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Invitrogen™ Factor XII Polyclonal Antibody
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Catalog No. PIPA5102461
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Quantity:
100 μL
Catalog No. Quantity
PIPA5102461 100 μL
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Catalog No. PIPA5102461

Supplier: Invitrogen™ PA5102461

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total Factor XII.

This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Factor XII
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene F12
Gene Accession No. D3ZTE0, P00748
Gene Alias beta-factor XIIa part 1; Beta-factor XIIa part 2; coagulation factor XII; coagulation factor XII (Hageman factor); coagulation factor XIIa heavy chain; Coagulation factor XIIa light chain; F12; F13; Factor 12; factor XII; Factor12; FXII; HAE3; HAEX; HAF; hageman factor
Gene Symbols F12
Host Species Rabbit
Immunogen A synthesized peptide derived from human F12(Accession P00748), corresponding to amino acid residues P566-S615.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2161, 306761
Target Species Human, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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