Invitrogen™ Factor XIII B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552004

Catalog No. PIPA552004

Description

Immunogen sequence: FCLAGYTTES GRQEEQTTCT TEGWSPEPRC FKKCTKPDLS NGYISDVKLL YKIQENMHYG CASGYKTTGG KDEEVVQCLS DGWSSQPTCR KEHETCLAPE LYNGNYSTTQ KTFKVKDKVQ YECATGYYTA GGKKTEEV Highest antigen sequence identity to the following orthologs: Mouse - 75%, Rat - 79%.

This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.

Specifications

• Antigen: Factor XIII B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: F13B
• Gene Alias: coagulation factor XIII B chain; coagulation factor XIII, B polypeptide; F13B; Fibrin-stabilizing factor B subunit; FXIIIB; Protein-glutamine gamma-glutamyltransferase B chain; TGase; transglutaminase B chain
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2165
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P05160
• Gene Symbols: F13B
• Immunogen: Recombinant protein corresponding to Human Factor XIII B. Recombinant protein control fragment (Product #RP-100497).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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