Invitrogen™ Factor XIII B Polyclonal Antibody

Catalog No.	Quantity
PIPA562563	100 μL

Catalog No. PIPA562563 Supplier Invitrogen™ Supplier No. PA562563

Description

Rabbit Polyclonal Antibody

Immunogen sequence: EMKWKYEGKV LHGDLIDFVC KQGYDLSPLT PLSELSVQCN RGEVKYPLCT RKESKGMCTS PPLIKHGVII SSTVDTYENG SSVEYRCFDH HFLEGSREAY CLDGMWTTPP LCLEPCTLSF TEMEKNNLLL KWDFDNRPHI LHGEY Highest antigen sequence identity to the following orthologs: Mouse - 76%, Rat - 74%.

This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.

Specifications

• Antigen: Factor XIII B
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: F13B
• Gene Accession No.: P05160
• Gene Alias: coagulation factor XIII B chain; coagulation factor XIII, B polypeptide; F13B; Fibrin-stabilizing factor B subunit; FXIIIB; Protein-glutamine gamma-glutamyltransferase B chain; TGase; transglutaminase B chain
• Gene Symbols: F13B
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human Factor XIII B. Recombinant protein control fragment (Product #RP-103115).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2165
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG