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Invitrogen™ Factor XIII B Polyclonal Antibody
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Catalog No. PIPA597725
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100 μg
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Catalog No. Quantity
PIPA597725 100 μg
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Catalog No. PIPA597725 Supplier Invitrogen™ Supplier No. PA597725
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Description

Rabbit Polyclonal Antibody

Factor XIII B Polyclonal Antibody for Western Blot, ELISA

This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Factor XIII B
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 4.17 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
Gene F13B
Gene Accession No. P05160
Gene Alias coagulation factor XIII B chain; coagulation factor XIII, B polypeptide; F13B; Fibrin-stabilizing factor B subunit; FXIIIB; Protein-glutamine gamma-glutamyltransferase B chain; TGase; transglutaminase B chain
Gene Symbols F13B
Host Species Rabbit
Immunogen Recombinant Human Coagulation factor XIII B chain protein (260-403AA).
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2165
Target Species Human
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG
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