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FADD Mouse anti-Human, Clone: OTI1C11, liquid, TrueMAB™
SDP

Catalog No. 501672578
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100 μL
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50-167-2578 100 μL
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Catalog No. 50-167-2578 Supplier OriGene Supplier No. TA501434
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Mouse Monoclonal Antibody

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

Specifications

Antigen FADD
Applications Flow Cytometry, Western Blot
Classification Monoclonal
Clone OTI1C11
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene FADD
Gene Accession No. Q13158
Gene Alias GIG3, MORT1
Gene Symbols FADD
Host Species Mouse
Immunogen Full length human recombit protein of human FADD produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8772
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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