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Invitrogen™ FADD Polyclonal Antibody
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Catalog No. PIPA5119104
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200 μL
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PIPA5119104 200 μL
PIPA5122008 20 μL
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Catalog No. PIPA5119104 Supplier Invitrogen™ Supplier No. PA5119104
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Description

Rabbit Polyclonal Antibody

FADD Polyclonal Antibody for Western Blot, IHC (P)

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FADD
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
Gene FADD
Gene Accession No. Q61160
Gene Alias Fadd; Fas (TNFRSF6)-associated via death domain; Fas associated via death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; Fas-associating protein with death domain; GIG3; Growth-inhibiting gene 3 protein; mediator of receptor induced toxicity; mediator of receptor-induced toxicity; MGC8528; MORT1; Mort1/FADD; protein FADD
Gene Symbols FADD
Host Species Rabbit
Immunogen Recombinant protein Fas Associating Death Domain Containing Protein. The antigen corresponds to amino acid range 7-178 of the target protein.
Purification Method Antigen affinity chromatography, Protein A
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14082, 266610
Target Species Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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