Invitrogen™ FADD Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA578260

Catalog No. PIPA578260

Description

Positive Control: HeLa, HeLa (30 μM Cisplatin treatment for 24 hr) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

Specifications

• Antigen: FADD
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FADD
• Gene Alias: Fadd; Fas (TNFRSF6)-associated via death domain; Fas associated via death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; Fas-associating protein with death domain; GIG3; Growth-inhibiting gene 3 protein; mediator of receptor induced toxicity; mediator of receptor-induced toxicity; MGC8528; MORT1; Mort1/FADD; protein FADD
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8772
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.58 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: Q13158
• Gene Symbols: FADD
• Immunogen: Recombinant protein encompassing a sequence within the center region of Human FADD. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG