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Invitrogen™ FADD Polyclonal Antibody
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Catalog No. PIPA581943
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100 μL
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PIPA581943 100 μL
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Catalog No. PIPA581943 Supplier Invitrogen™ Supplier No. PA581943
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LTELKFLCLG RVGKRKLERV QSGLDLFSML LEQNDLEPGH TELLRELLAS LRRHDLLRRV DDFEAGAAAG AAPGEEDLCA AFNVICDNVG KDWRRLARQL KVSDTKIDSI EDRYPRNLTE RVRESLRIWK N Highest antigen sequence indentity to the following orthologs: Rat - 76%, Mouse - 75%.

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FADD
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene FADD
Gene Accession No. Q13158
Gene Alias Fadd; Fas (TNFRSF6)-associated via death domain; Fas associated via death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; Fas-associating protein with death domain; GIG3; Growth-inhibiting gene 3 protein; mediator of receptor induced toxicity; mediator of receptor-induced toxicity; MGC8528; MORT1; Mort1/FADD; protein FADD
Gene Symbols FADD
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human FADD. Recombinant protein control fragment (Product #RP-95401).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8772
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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