Invitrogen™ FAIM3 Monoclonal Antibody (OTI1E6)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA526353

Catalog No. PIMA526353

Description

FAIM3 Monoclonal Antibody for IHC (P)

Apoptosis is an important process by which normal tissue homeostasis and function are maintained. One of the major signals that regulate this process is mediated by the activation of the Fas receptor by its ligand. This leads to the formation of a Fas-associated death domain (FADD)- containing death-inducing signaling complex and the activation of caspase-8, which in turn activates downstream effector caspases, such as caspase-3 and -7. Recent experiments have shown that overexpression of Toso, a novel regulator of Fas-induced apoptosis in lymphoid cells, in Jurkat cells as well as transgenic mice render these cells resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Furthermore, Toso was found to associate with FADD, suggesting that Toso functions by disrupting the formation of the death-inducing signaling complex.

Specifications

• Antigen: FAIM3
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O60667
• Gene Symbols: Fcmr
• Immunogen: Full length human recombinant protein of FAIM3 produced in HEK293 Cells.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin)
• Clone: OTI1E6
• Conjugate: Unconjugated
• Gene: Fcmr
• Gene Alias: 1810037B05Rik; Faim3; Fas apoptotic inhibitory molecule 3; Fc fragment of IgM receptor; Fc mu receptor; FCMR; FcmuR; IgM Fc fragment receptor; IgM Fc receptor; immunoglobulin mu Fc receptor; regulator of Fas-induced apoptosis Toso; TOSO
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9214
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid