Invitrogen™ FAIM3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5109706

Catalog No. PIPA5109706

Description

Immunogen sequence: RILPEVKVEG ELGGSVTIKC PLPEMHVRIY LCREMAGSGT CGTVVSTTNF IKAEYKGRVT LKQYPRKNLF LVEVTQLTES DSGVYACGAG MNTDRGKTQK VTLNVHSEYE PSWEEQPMPE TPKWFHLPYL FQMPAYASSS KFVTRVTTPA QRGKVPPVHH SSPTTQITHR PRVSRASSVA GDKPRTFLPS TTASKISALE GLLKPQTPSY NHHTRLHRQR ALDYGSQSGR EGQG.

Apoptosis is an important process by which normal tissue homeostasis and function are maintained. One of the major signals that regulate this process is mediated by the activation of the Fas receptor by its ligand. This leads to the formation of a Fas-associated death domain (FADD)- containing death-inducing signaling complex and the activation of caspase-8, which in turn activates downstream effector caspases, such as caspase-3 and -7. Recent experiments have shown that overexpression of Toso, a novel regulator of Fas-induced apoptosis in lymphoid cells, in Jurkat cells as well as transgenic mice render these cells resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Furthermore, Toso was found to associate with FADD, suggesting that Toso functions by disrupting the formation of the death-inducing signaling complex.

Specifications

• Antigen: FAIM3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Fcmr
• Gene Alias: 1810037B05Rik; Faim3; Fas apoptotic inhibitory molecule 3; Fc fragment of IgM receptor; Fc mu receptor; FCMR; FcmuR; IgM Fc fragment receptor; IgM Fc receptor; immunoglobulin mu Fc receptor; regulator of Fas-induced apoptosis Toso; TOSO
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 548326, 69169, 9214
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.69 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: A1KXC4, O60667, Q5M871
• Gene Symbols: Fcmr
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 18-251 of human FAIM3 (NP_005440.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG