Invitrogen™ FAM175B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA558027

Catalog No. PIPA558027

Description

Immunogen sequence: DVEKSERVVE SCQAEVNKLR RQITQRKNEK EQERRLQQAV LSRQMPSESL DPAFSPRMPS SGFAAEGRST LGDA Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 92%.

Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins. Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148). [UniProt].

Specifications

• Antigen: FAM175B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ABRAXAS2
• Gene Alias: AA589499; Abraxas brother; abraxas brother 1; abraxas brother protein 1; Abraxas2; Abro1; AI853413; BRISC complex subunit Abraxas 2; BRISC complex subunit Abro1; C430003P19Rik; Em:AC068896.4; FAM175B; family with sequence similarity 175 member B; family with sequence similarity 175, member B; KIAA0157; Protein FAM175B; RGD1308918
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23172
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q15018
• Gene Symbols: ABRAXAS2
• Immunogen: Recombinant protein corresponding to Human FAM175B. Recombinant protein control fragment (Product #RP-102776).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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