Invitrogen™ FAM193B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5140060

Catalog No. PIPA5140060

Description

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: NTVPNLSRVI WVKTPKPGYP SSEEPSSKEV PSCKQELPEP VSSGGKPQKG KRQGSQAKKS EASPAPRPPA SLEVPSAKGQ VAGPKQ.

FAM193B, also known as IRIZIO, was initially identified as a protein that is upregulated in alveolar rhabdomyosarcoma (ARMS), a type of fast-growing tumor characterized by chromosomal translocations fusing the PAX3 or PAX7 gene with that of FOXO1. It has been suggested that, in addition to the PAX3-FOXO1 gene fusion, disruption of the Rb and p53 pathways is required for full ARMS tumorigenesis. In PAX3-FOXO1-expressing primary mouse fibroblasts that possessed a defective p53 pathway, FAM193B expression enabled the tumorigenic transformation, suggesting that FAM193B may contribute to rhabdomyosarcomagenesis in humans.

Specifications

• Antigen: FAM193B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FAM193B
• Gene Alias: FAM193B; family with sequence similarity 193 member B; IRIZIO; KIAA1931; Protein FAM193B
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54540
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96PV7
• Gene Symbols: FAM193B
• Immunogen: Recombinant protein corresponding to Human FAM193B. Recombinant protein control fragment (Product #RP-106816).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG