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Invitrogen™ FAM193B Polyclonal Antibody
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Catalog No. PIPA534440
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100 μg
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Catalog No. Quantity
PIPA534440 100 μg
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Catalog No. PIPA534440 Supplier Invitrogen™ Supplier No. PA534440
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Description

Rabbit Polyclonal Antibody

A suggested positive control is Jurkat cell lysate. PA5-34440 can be used with blocking peptide PEP-1482.

FAM193B, also known as IRIZIO, was initially identified as a protein that is upregulated in alveolar rhabdomyosarcoma (ARMS), a type of fast-growing tumor characterized by chromosomal translocations fusing the PAX3 or PAX7 gene with that of FOXO1. It has been suggested that, in addition to the PAX3-FOXO1 gene fusion, disruption of the Rb and p53 pathways is required for full ARMS tumorigenesis. In PAX3-FOXO1-expressing primary mouse fibroblasts that possessed a defective p53 pathway, FAM193B expression enabled the tumorigenic transformation, suggesting that FAM193B may contribute to rhabdomyosarcomagenesis in humans.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FAM193B
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene FAM193B
Gene Accession No. Q96PV7
Gene Alias FAM193B; family with sequence similarity 193 member B; IRIZIO; KIAA1931; Protein FAM193B
Gene Symbols FAM193B
Host Species Rabbit
Immunogen A 16 amino acid synthetic peptide near the amino terminus of human FAM193B.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54540
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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