Invitrogen™ FAM49B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552647

Catalog No. PIPA552647

Description

Immunogen sequence: GNLLKVLTCT DLEQGPNFFL DFENAQPTES EKEIYNQVNV VLKDAEGILE DLQSYRGAGH EIREAIQHPA DEKLQEKAWG AVVPLVGKLK KFYEFSQRLE AALRGLLGAL TSTPYSPTQH LEREQALAKQ FAE Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling (PubMed:31285585, PubMed:30250061). Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE-induced actin polymerization (PubMed:30250061). Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE-mediated bacterial entry (PubMed:31285585). Restricts also infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes. Involved in the regulation of mitochondrial dynamics and oxidative stress (PubMed:29059164). [UniProt].

Specifications

• Antigen: FAM49B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CYRIB
• Gene Alias: 0910001A06Rik; AW122079; BM-009; FAM49B; family with sequence similarity 49 member B; family with sequence similarity 49, member B; L1; Protein FAM49B; RGD1307697
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 51571
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9NUQ9
• Gene Symbols: CYRIB
• Immunogen: Recombinant protein corresponding to Human FAM49B. Recombinant protein control fragment (Product #RP-89928).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov