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Invitrogen™ FAM49B Polyclonal Antibody
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Catalog No. PIPA552647
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100 μL
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PIPA552647 100 μL
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Catalog No. PIPA552647 Supplier Invitrogen™ Supplier No. PA552647
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: GNLLKVLTCT DLEQGPNFFL DFENAQPTES EKEIYNQVNV VLKDAEGILE DLQSYRGAGH EIREAIQHPA DEKLQEKAWG AVVPLVGKLK KFYEFSQRLE AALRGLLGAL TSTPYSPTQH LEREQALAKQ FAE Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling (PubMed:31285585, PubMed:30250061). Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE-induced actin polymerization (PubMed:30250061). Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE-mediated bacterial entry (PubMed:31285585). Restricts also infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes. Involved in the regulation of mitochondrial dynamics and oxidative stress (PubMed:29059164). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen FAM49B
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene CYRIB
Gene Accession No. Q9NUQ9
Gene Alias 0910001A06Rik; AW122079; BM-009; FAM49B; family with sequence similarity 49 member B; family with sequence similarity 49, member B; L1; Protein FAM49B; RGD1307697
Gene Symbols CYRIB
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human FAM49B. Recombinant protein control fragment (Product #RP-89928).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51571
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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