Invitrogen™ FAM83B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA556755

Catalog No. PIPA556755

Description

Immunogen sequence: NHSVALNQTT NGHTESNNYI YKTLGVNKQT ENLKNQQTEN LLKRRSFPLF DNSKANLDPG NSKHYVYSTL TRNRVRQPEK PKEDLLKSSK SM Highest antigen sequence identity to the following orthologs: Mouse - 72%, Rat - 71%.

The FAM83B gene, also known as Family With Sequence Similarity 83 Member B, is located on chromosome 6q22.1. This gene encodes a protein that functions as an oncogene and plays a crucial role in the development and progression of various human cancers including breast, prostate, and endometrial cancers. FAM83B exerts its oncogenic effects primarily through the PI3K/AKT/mTOR signaling pathway, promoting cell proliferation, migration, and invasion while inhibiting apoptosis. Additionally, FAM83B has been found to regulate mitochondrial metabolism and maintain cellular energy homeostasis. Knockdown studies of FAM83B in cancer cell lines have demonstrated significant reductions in tumor growth and metastatic potential, highlighting its potential as a therapeutic target. The gene includes multiple exons and undergoes alternative splicing, contributing to its functional diversity.

Specifications

• Antigen: FAM83B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FAM83B
• Gene Alias: C6orf143; FAM83B; family with sequence similarity 83 member B; family with sequence similarity 83, member B; protein FAM83B
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 222584
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q5T0W9
• Gene Symbols: FAM83B
• Immunogen: Recombinant protein corresponding to Human FAM83B. Recombinant protein control fragment (Product #RP-94944).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov