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Invitrogen™ FAM83B Polyclonal Antibody
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Catalog No. PIPA528548
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100 μL
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PIPA528548 100 μL
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Catalog No. PIPA528548 Supplier Invitrogen™ Supplier No. PA528548
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: A549, MCF-7. Predicted reactivity: Mouse (89%), Rat (89%), Rhesus Monkey (98%), Bovine (90%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The FAM83B gene, also known as Family With Sequence Similarity 83 Member B, is located on chromosome 6q22.1. This gene encodes a protein that functions as an oncogene and plays a crucial role in the development and progression of various human cancers including breast, prostate, and endometrial cancers. FAM83B exerts its oncogenic effects primarily through the PI3K/AKT/mTOR signaling pathway, promoting cell proliferation, migration, and invasion while inhibiting apoptosis. Additionally, FAM83B has been found to regulate mitochondrial metabolism and maintain cellular energy homeostasis. Knockdown studies of FAM83B in cancer cell lines have demonstrated significant reductions in tumor growth and metastatic potential, highlighting its potential as a therapeutic target. The gene includes multiple exons and undergoes alternative splicing, contributing to its functional diversity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FAM83B
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.01% thimerosal; pH 7
Gene FAM83B
Gene Accession No. Q5T0W9
Gene Alias C6orf143; FAM83B; family with sequence similarity 83 member B; family with sequence similarity 83, member B; protein FAM83B
Gene Symbols FAM83B
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the N-terminus region of human FAM83B. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 222584
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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