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Tocris™ Famotidine

Catalog No. 7290100
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100 mg
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Catalog No. Quantity
72-901-00 100 mg
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Catalog No. 72-901-00 Supplier Tocris™ Supplier No. 7290/100
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Description

Potent and high affinity H2 biased inverse agonist

Famotidine is a potent and high affinity histamine H2 receptor biased inverse agonist (Kd = 14 nM, IC50 = 33 nM). Reduces basal receptor activity by 75%. Inhibits Gs-mediated pathways but acts as a partial agonist of β-arrestin recruitment (EC50 = 105 nM). Inhibits gastric acid secretion and histamine-induced mast cell activation. Also inhibits HIV replication in vitro.

Specifications

Chemical Name or Material 3-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]-N-(aminosulfonyl)propanimidamide
CAS 76824-35-6
Quantity 100 mg
Target Histamine H2 Receptor Antagonists
Molecular Formula C8H15N7O2S3
Purity 0.98
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