Invitrogen™ FANCD2 Monoclonal Antibody (FI-17)

Catalog No.	Quantity
AMPA6570	100 μL

Catalog No. AMPA6570 Supplier Invitrogen™ Supplier No. MA116570

Description

Mouse Monoclonal Antibody

By Western blot, this antibody recognizes a band at ~155 and ~162 kDa (post-translationally modified form). Suggested positive control: Hela whole cell extract.

FANCD2 (Fanconi anemia group D2 protein) is required for maintenance of chromosomal stability. It promotes accurate and efficient pairing of homologs during meiosis. FANCD2 is involved in the repair of DNA double-stranded breaks, both by homologous recombination and single-stranded annealing. It is required for the targeting/stabilization of BLM to non-centromeric abnormal structures induced by replicative stress. FANCD2 promotes BRCA2/FANCD1 loading onto damaged chromatin. Defects in the FANCD2 gene result in Fanconi anemia complementation group D2. This disorder affects all bone marrow elements resulting in anemia, leukopenia, and thrombopenia.

Specifications

• Antigen: FANCD2
• Applications: ChIP Assay, Immunoprecipitation, Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: FI-17
• Concentration: Conc. Not Determined
• Conjugate: Unconjugated
• Formulation: Ascites with 0.1% sodium azide
• Gene: FANCD2
• Gene Accession No.: Q80V62, Q9BXW9
• Gene Alias: 2410150O07Rik; AU015151; BB137857; DKFZp762A223; FA4; FACD; FACD2; FAD; FAD2; FA-D2; FANCD; FANCD2; Fanconi anemia complementation group D2; Fanconi anemia D2 protein; Fanconi anemia group D2 protein; Fanconi anemia group D2 protein homolog; Fanconi anemia, complementation group D2; FLJ23826; Protein FACD2
• Gene Symbols: FANCD2
• Host Species: Mouse
• Immunogen: Human FANCD2 fusion protein.
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 211651, 2177
• Target Species: Human, Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1