Invitrogen™ FANCD2 Monoclonal Antibody (FI-17)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA116570

Catalog No. AMPA6570

Description

By Western blot, this antibody recognizes a band at ~155 and ~162 kDa (post-translationally modified form). Suggested positive control: Hela whole cell extract.

FANCD2 (Fanconi anemia group D2 protein) is required for maintenance of chromosomal stability. It promotes accurate and efficient pairing of homologs during meiosis. FANCD2 is involved in the repair of DNA double-stranded breaks, both by homologous recombination and single-stranded annealing. It is required for the targeting/stabilization of BLM to non-centromeric abnormal structures induced by replicative stress. FANCD2 promotes BRCA2/FANCD1 loading onto damaged chromatin. Defects in the FANCD2 gene result in Fanconi anemia complementation group D2. This disorder affects all bone marrow elements resulting in anemia, leukopenia, and thrombopenia.

Specifications

• Antigen: FANCD2
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: ascites with 0.1% sodium azide
• Gene Accession No.: Q9BXW9
• Gene Symbols: FANCD2
• Immunogen: FANCD2 fusion protein.
• Regulatory Status: RUO
• Gene ID (Entrez): 2177
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ChIP Assay, Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: FI-17
• Conjugate: Unconjugated
• Gene: FANCD2
• Gene Alias: 2410150O07Rik; AU015151; BB137857; DKFZp762A223; FA4; FACD; FACD2; FAD; FAD2; FA-D2; FANCD; FANCD2; Fanconi anemia complementation group D2; Fanconi anemia D2 protein; Fanconi anemia group D2 protein; Fanconi anemia group D2 protein homolog; Fanconi anemia, complementation group D2; FLJ23826; Protein FACD2
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1