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FAP1 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501986781
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50-198-6781 100 μL
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Catalog No. 50-198-6781 Supplier Bioss Supplier No. BS5760R
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Description

Rabbit Polyclonal Antibody

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.

Specifications

Antigen FAP1
Applications Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene PTPN13
Gene Accession No. Q12923
Gene Alias DKFZp686J1497; FAP-1; Fas-associated protein-tyrosine phosphatase 1; hPTP1E; hPTPE1; PNP1; protein tyrosine phosphatase, non-receptor type 13; protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase); Protein-tyrosine phosphatase 1E; Protein-tyrosine phosphatase PTPL1; PTP1E; PTP-BAS; PTP-BL; PTP-E1; PTPL1; PTPLE; PTPN13; Tyrosine-protein phosphatase non-receptor type 13
Gene Symbols PTPN13
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human FAP1/PTPN13.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5783
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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