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  5. Tocris Bioscience™ Fasudil hydrochloride

Tocris Bioscience™ Fasudil hydrochloride
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Catalog No. 054150
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50 mg
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Catalog No. Quantity
05-415-0 50 mg
05-411-0 10 mg
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Catalog No. 05-415-0 Supplier Tocris Bioscience™ Supplier No. 0541/50
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Description

Inhibitor of cyclic nucleotide dependent- and Rho-kinases

Fasudil hydrochloride is a cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM). Fasudil suppresses MMP-2 expression and induces apoptosis in glioblastoma cells in vivo. Fasudil is a Ca2+ antagonist, vasodilator and inhibits proliferation of vascular smooth muscle cells. Fasudil binds to α-synuclein to reduce aggregate formation in cellular models of Parkinson's disease, also displays neuroprotective properties and increases survival of dopaminergic neurons in vivo.

Chemical Identifiers

CAS 105628-07-7
Molecular Formula C14H18ClN3O2S

Specifications

Quantity 50 mg
Formula Weight 327.83
Purity >98%
Molecular Weight (g/mol) 327.827
Chemical Name or Material Fasudil hydrochloride

Safety and Handling

Recommended Storage Store at Room Temperature
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