Invitrogen™ FAT4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA562694

Catalog No. PIPA562694

Description

Immunogen sequence: FDDPDNIPPY GDDMTVRKQP EGNPKPDIIE RENPYLIYDE TDIPHNSETI PSAPLASPEQ EIEHYDIDNA SSIAPSDADI IQHYKQFRSH T Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.

FAT1, FAT2, FAT3 and FAT4 are human homologs of Drosophila Fat, which is involved in tumor suppression and planar cell polarity (PCP). FAT4 undergo the first proteolytic cleavage by Furin and are predicted to undergo the second cleavage by secretase to release intracellular domain (ICD). FAT4 directly interacts with MPDZ/MUPP1 to recruit membrane associated guanylate kinase MPP5/PALS1. FAT4 is involved in the maintenance of PCP and inhibition of cell proliferation.

Specifications

• Antigen: FAT4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FAT4
• Gene Alias: 6030410K14Rik; 9430004M15; Cadherin family member 14; cadherin-related family member 11; CDHF14; CDHR11; FAT atypical cadherin 4; FAT tumor suppressor homolog 4; FAT tumor suppressor homolog 4 (Drosophila); FAT4; Fatj; FAT-J; fat-like cadherin protein FAT-J; hFat4; HKLLS2; Nbla00548; protocadherin Fat 4; putative protein product of Nbla00548; RGD1564291; VMLDS2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 79633
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q6V0I7
• Gene Symbols: FAT4
• Immunogen: Recombinant protein corresponding to Human FAT4. Recombinant protein control fragment (Product #RP-101703).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG