FBW7 Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Rabbit Polyclonal Antibody

Supplier:  Bethyl Laboratories, Inc A301721AT

Catalog No. 50-155-9533

Description

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Cyclin E, one of the activators of the cyclin-dependent kinase Cdk2, is critical for the initiation of DNA replication and other S-phase functions. The proper timing and amplitude of cyclin E expression seem to be important, because elevated levels of cyclin E have been associated with a variety of maligcies and constitutive expression of cyclin E leads to genomic instability. Phosphorylated cyclin E depends on the novel human gene, hCdc4, that was found to be mutated in a cell line derived from breast cancer that expressed extremely high levels of cyclin E.

Specifications

• Antigen: FBW7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FBXW7
• Gene Alias: AGO, archipelago, Archipelago homolog, archipelago homolog (Drosophila), CDC4, F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase, F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila), F-box and WD-40 domain-containing protein 7, F-box protein FBW7, F-box protein FBX30, F-box protein SEL-10, FBW6, FBW7, FBX30, FBXO30, FBXW6, FLJ11071, hAgo, hCdc4, homolog of C elegans sel-10, SEL10, SEL-10
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55294
• Content And Storage: 4° C
• Form: Liquid

• Applications: Immunohistochemistry, Immunoprecipitation
• Concentration: 1 mg/ml
• Formulation: phosphate, tris citrate with 0.09% sodium azide; pH 7-8
• Gene Accession No.: Q969H0
• Gene Symbols: FBXW7
• Immunogen: Between 50 and 100
• Quantity: 10 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG