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Invitrogen™ FBXL20 Polyclonal Antibody
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Catalog No. PIPA560814
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100 μL
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PIPA560814 100 μL
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Catalog No. PIPA560814 Supplier Invitrogen™ Supplier No. PA560814
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MRRDVNGVTK SRFEMFSNSD EAVINK Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

Members of the F-box protein family, such as Scrapper, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. Scrapper is selectively expressed in the brain, broadly expressed within the mouse CNS and is abundant at presynaptic membrane. Scrapper has orthologs in C. elegans, D. melanogaster, and mammals which suggests that it might function as an important membrane-localized E3 ligase in various species. Scrapper is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to critically regulate synaptic transmission. This identifies protein degradation as a mechanism for holding synaptic communication in check.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FBXL20
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene FBXL20
Gene Accession No. Q96IG2
Gene Alias 2610511F20Rik; 4632423N09Rik; AI849362; AL117906; C86145; Fbl2; Fbl20; F-box and leucine rich repeat protein 20; F-box and leucine-rich repeat protein 20; F-box protein FBL2; F-box/LRR-repeat protein 20; F-box/LRR-repeat protein 2-like; Fbxl2; Fbxl20; mKIAA4147; Scr; scrapper
Gene Symbols FBXL20
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human FBXL20. Recombinant protein control fragment (Product #RP-100020).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 84961
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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