Invitrogen™ FBXL20 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA562180

Catalog No. PIPA562180

Description

Immunogen sequence: IGAHCPELVT LNLQTCLQIT DEGLIT Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

Members of the F-box protein family, such as Scrapper, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. Scrapper is selectively expressed in the brain, broadly expressed within the mouse CNS and is abundant at presynaptic membrane. Scrapper has orthologs in C. elegans, D. melanogaster, and mammals which suggests that it might function as an important membrane-localized E3 ligase in various species. Scrapper is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to critically regulate synaptic transmission. This identifies protein degradation as a mechanism for holding synaptic communication in check.

Specifications

• Antigen: FBXL20
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FBXL20
• Gene Alias: 2610511F20Rik; 4632423N09Rik; AI849362; AL117906; C86145; Fbl2; Fbl20; F-box and leucine rich repeat protein 20; F-box and leucine-rich repeat protein 20; F-box protein FBL2; F-box/LRR-repeat protein 20; F-box/LRR-repeat protein 2-like; Fbxl2; Fbxl20; mKIAA4147; Scr; scrapper
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 84961
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96IG2
• Gene Symbols: FBXL20
• Immunogen: Recombinant protein corresponding to Human FBXL20. Recombinant protein control fragment (Product #RP-100021).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov