Invitrogen™ FBXO15 Monoclonal Antibody (612834)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA524277

Catalog No. PIMA524277

Description

Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

F-box protein 15 (FBXO15) is a gene located on chromosome 20p11.1 that encodes a member of the F-box protein family, known for their role in ubiquitin-mediated proteolysis. Proteins in this family contain an F-box domain, enabling them to form part of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which targets specific proteins for ubiquitination and subsequent degradation. FBXO15 is involved in regulating various cellular processes by controlling the turnover of proteins related to cell cycle progression, signal transduction, and development. Its function is crucial for maintaining cellular homeostasis, where dysregulation of FBXO15 can impact protein degradation pathways, potentially leading to disorders such as cancer due to uncontrolled cell proliferation. Current research is focused on understanding the specific targets and functions of FBXO15 within the ubiquitin proteasome system and its potential as a therapeutic target in diseases characterized by aberrant proteolytic activity.

Specifications

• Antigen: FBXO15
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q8NCQ5
• Gene Symbols: FBXO15
• Immunogen: E. coli-derived recombinant human F-box protein 15/FBXO15 isoform 2 Asn298-Tyr434.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Flow Cytometry, Immunocytochemistry
• Clone: 612834
• Conjugate: Unconjugated
• Gene: FBXO15
• Gene Alias: AU019763; ecat3; F-box only protein 15; F-box protein 15; FBX15; FBXO15; MGC39671
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 201456
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized