Invitrogen™ FBXO15 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA528530

Catalog No. PIPA528530

Description

Recommended positive controls: Raji, Human ESC. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

F-box protein 15 (FBXO15) is a gene located on chromosome 20p11.1 that encodes a member of the F-box protein family, known for their role in ubiquitin-mediated proteolysis. Proteins in this family contain an F-box domain, enabling them to form part of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which targets specific proteins for ubiquitination and subsequent degradation. FBXO15 is involved in regulating various cellular processes by controlling the turnover of proteins related to cell cycle progression, signal transduction, and development. Its function is crucial for maintaining cellular homeostasis, where dysregulation of FBXO15 can impact protein degradation pathways, potentially leading to disorders such as cancer due to uncontrolled cell proliferation. Current research is focused on understanding the specific targets and functions of FBXO15 within the ubiquitin proteasome system and its potential as a therapeutic target in diseases characterized by aberrant proteolytic activity.

Specifications

• Antigen: FBXO15
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FBXO15
• Gene Alias: AU019763; ecat3; F-box only protein 15; F-box protein 15; FBX15; FBXO15; MGC39671
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 201456
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q8NCQ5
• Gene Symbols: FBXO15
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 246 of Human FBXO15.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG