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Invitrogen™ FBXO15 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA528530

Catalog No. PIPA528530


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Description

Description

Recommended positive controls: Raji, Human ESC. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

F-box protein 15 (FBXO15) is a gene located on chromosome 20p11.1 that encodes a member of the F-box protein family, known for their role in ubiquitin-mediated proteolysis. Proteins in this family contain an F-box domain, enabling them to form part of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which targets specific proteins for ubiquitination and subsequent degradation. FBXO15 is involved in regulating various cellular processes by controlling the turnover of proteins related to cell cycle progression, signal transduction, and development. Its function is crucial for maintaining cellular homeostasis, where dysregulation of FBXO15 can impact protein degradation pathways, potentially leading to disorders such as cancer due to uncontrolled cell proliferation. Current research is focused on understanding the specific targets and functions of FBXO15 within the ubiquitin proteasome system and its potential as a therapeutic target in diseases characterized by aberrant proteolytic activity.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

FBXO15
Polyclonal
Unconjugated
FBXO15
AU019763; ecat3; F-box only protein 15; F-box protein 15; FBX15; FBXO15; MGC39671
Rabbit
Antigen Affinity Chromatography
RUO
201456
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Western Blot
1 mg/mL
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Q8NCQ5
FBXO15
Recombinant fragment corresponding to a region within amino acids 1 and 246 of Human FBXO15.
100 μL
Primary
Human
Antibody
IgG
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