Invitrogen™ FBXW2 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA518189

Catalog No. PIPA518189

Description

This antibody is predicted to react with bovine, canine and porcine based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.

F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.

Specifications

• Antigen: FBXW2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FBXW2
• Gene Alias: 2700071L08Rik; EMBL:AAI66990.1}; F-box and WD repeat domain containing 2; F-box and WD-40 domain protein 2; F-box and WD-40 domain-containing protein 2; F-box and WD-40 domain-containing protein 2 {ECO:0000312; F-box protein Fbw2; F-box/WD repeat-containing protein 2; FBW2; FBXW2; fbxw2 {ECO:0000312; FWD2; MD6; MGC117371; Protein MD6; RGD:1310460}
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 26190, 30050, 311881
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: B2RZ17, Q60584, Q9UKT8
• Gene Symbols: FBXW2
• Immunogen: Synthetic peptide sequence (KRGSSFLAGEHPG) corresponding to the C-terminus amino acids of FBXW2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG