FBXW4 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-6486	Proteintech Group Inc 106571AP150UL	150 μL

Description

This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22.

Specifications

• Antigen: FBXW4
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: P57775, Q9JMJ2
• Gene ID (Entrez): 30838, 309444, 6468
• Immunogen: FBXW4 Fusion Protein Ag1047
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: FBXW4

• Concentration: 0.17 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: DAC, Dactylin, FBW4, FBWD4, FBXW4, SHFM3, SHSF3
• Gene Symbols: Fbxw4
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody