Invitrogen™ FBXW5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA597208

Catalog No. PIPA597208

Description

Immunogen sequence: VRNKPYDVFG CWLTETSLIS GNLHRIGDIT SCSVLWLNNA FQDVESENVN VVKRLFKIQN LNASTVRTVM VADCSRFDSP DLLLEAGDPA TSPCRIFDLG SDNEEVVAGP APAHAKEGLR HFLDRVLEGR AQPQLSERML ETKVAELLAQ GHTKPPERSA TGAKSKYLIF TTGCLTYSPH QIGIKQILPH QMTTAGPVLG EGRGSDAFFD ALDHVIDIHG HIIGMGLSPD NRYLYVNSRA WPNGAVVADP MQPPPIAEEI DLLVFDLKTM REVRRALRAH RAYTPNDECF FIFLDVSRDF VASGAEDRHG YIWDRHYNIC LARLRHEDVV NSVVFSPQEQ ELLLTASDDA TIKAWRSPRT MRVLQAPRPR PRTFFSWLAS QRR Positive Samples: A-549; Cellular Location: Cytoplasm.

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented.

Specifications

• Antigen: FBXW5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FBXW5
• Gene Alias: AI159739; F-box and WD repeat domain containing 5; F-box and WD-40 domain protein 5; F-box and WD-40 domain-containing protein 5; F-box protein Fbw5; F-box/WD repeat-containing protein 5; FBW5; Fbxw5; PP3971; WD repeat-containing F-box protein FBW5
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54461
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 2.33 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q969U6
• Gene Symbols: FBXW5
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 184-566 of human FBXW5 (NP_0618711).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG