FBXW7 Monoclonal Antibody (OTI2E12), TrueMAB™, OriGene

Catalog No.	Quantity
50-167-9452	100 μL

Catalog No. 50-167-9452 Supplier OriGene Supplier No. TA802858

Description

Mouse Monoclonal Antibody

Cyclin E, one of the activators of the cyclin-dependent kinase Cdk2, is critical for the initiation of DNA replication and other S-phase functions. The proper timing and amplitude of cyclin E expression seem to be important, because elevated levels of cyclin E have been associated with a variety of maligcies and constitutive expression of cyclin E leads to genomic instability. Phosphorylated cyclin E depends on the novel human gene, hCdc4, that was found to be mutated in a cell line derived from breast cancer that expressed extremely high levels of cyclin E.

Specifications

• Antigen: FBXW7
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI2E12
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: FBXW7
• Gene Accession No.: Q969H0
• Gene Alias: AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4
• Gene Symbols: FBXW7
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-354 of human FBXW7 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 55294
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a