FBXW7 Mouse anti-Human, Clone: OTI6B1, lyophilized, TrueMAB™

Catalog No.	Quantity
50-166-6306	100 μg

Catalog No. 50-166-6306 Supplier OriGene Supplier No. CF803051

Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Cyclin E, one of the activators of the cyclin-dependent kinase Cdk2, is critical for the initiation of DNA replication and other S-phase functions. The proper timing and amplitude of cyclin E expression seem to be important, because elevated levels of cyclin E have been associated with a variety of maligcies and constitutive expression of cyclin E leads to genomic instability. Phosphorylated cyclin E depends on the novel human gene, hCdc4, that was found to be mutated in a cell line derived from breast cancer that expressed extremely high levels of cyclin E.

Specifications

• Antigen: FBXW7
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI6B1
• Conjugate: Unconjugated
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene: FBXW7
• Gene Accession No.: Q969H0
• Gene Alias: AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4
• Gene Symbols: FBXW7
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-354 of human FBXW7 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 55294
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG2b