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Tocris Bioscience™ FC 11
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Catalog No. 73062
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73-062 2 mg
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Catalog No. 73-062 Supplier Tocris Bioscience™ Supplier No. 7306/2
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Description

Highly potent focal adhesion kinase (FAK) Degrader (PROTAC™)

FC 11 is a highly potent focal adhesion kinase (FAK) PROTAC™ Degrader (DC50 values are 40 to 370 pM depending on cell line), which is composed of the FAK inhibitor PF 562217 joined by a linker to the cereblon-binding ligand Pomalidomide (Cat. No. 6302). The effects of FC 11 are reversible upon compound wash out. FC 11 also degrades autophosphorylated FAK (pFAKtyr397), displaying near complete degradation after 3 hours at 100 nM in TM3 cells.

PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

Chemical Name or Material 1-[2-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1 H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-N-[4-[[4-[[[2-[methyl(methylsulfonyl)amino]-3-pyridinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]phenyl]-1 H-1,2,3-triazole-4-carboxamid
CAS 2271035-37-9
Quantity 2 mg
Target FAK
Molecular Formula C41H42F3N13O9S
Purity 0.98
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