Fc gamma RIIIA/CD16a Antibody (3G8), DyLight 680, Novus Biologicals™

Rabbit Monoclonal Antibody

Supplier:  Novus Biologicals NBP281102FR

Catalog No. NB016125

Description

Fc gamma RIIIA/CD16a Monoclonal specifically detects Fc gamma RIIIA/CD16a in Human, Baboon, Chimpanzee, Cynomolgus Monkey, Rhesus Macaque samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence.

Specifications

• Antigen: Fc gamma RIIIA/CD16a
• Classification: Monoclonal
• Conjugate: DyLight 680
• Formulation: 50mM Sodium Borate
• Gene Symbols: FCGR3A
• Immunogen: 3G8 was prepared by immunizing mice with human PMN (polymorphonuclear leukocytes) cells.
• Quantity: 0.1 mL
• Research Discipline: Cell Biology, Cellular Markers, Cytokine Research, Growth and Development, Hematopoietic Stem Cell Markers, Immunology, Innate Immunity, Neuronal Cell Markers, Neuroscience, Stem Cell Markers, Stem Cells
• Gene ID (Entrez): 2214
• Target Species: Human, Baboon, Chimpanzee, Cynomolgus Monkey, Rhesus Macaque
• Form: Purified

• Applications: Flow Cytometry, Immunohistochemistry, Immunocytochemistry, Immunofluorescence
• Clone: 3G8
• Dilution: Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence
• Gene Alias: CD16a, CD16a antigen, CD16FCRIIIA, Fc fragment of IgG, low affinity IIIa, receptor (CD16a), Fc fragment of IgG, low affinity IIIa, receptor for (CD16), Fc gamma receptor III-A, FCG3, Fc-gamma receptor III-2 (CD 16), Fc-gamma receptor IIIb (CD16), Fc-gamma RIII, Fc-gamma RIIIa, Fc-gamma RIII-alpha, FCGR3, FCGRIII, FCR-10, FcRIII, FcRIIIa, IGFR3FcgammaRIIIA, immunoglobulin G Fc receptor III, low affinity III, receptor for (CD16), low affinity immunoglobulin gamma Fc region receptor III-A, neutrophil-specific antigen NA
• Host Species: Rabbit
• Purification Method: Protein A purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: 3G8 binds to CD16 at an epitope which is not the IgG-binding site. This antibody cannot distinguish between CD16a transmembrane isoform found on the surface of NK cells and macrophages (which can trigger the cytolytic response), and the GPI-linked CD16b isoform present on neutrophils or soluble CD16 found in the plasma. CD16 is the low affinity IgG receptor III and binds to aggregated IgG or IgG-antigen complex which functions in NK cell activation, phagocytosis and ADCC (antibody-dependent cell-mediated cytotoxicity).
• Content And Storage: Store at 4°C in the dark.
• Isotype: IgG κ