Invitrogen™ FceR1 alpha Monoclonal Antibody (CRA2 (AER24))

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA14998

Catalog No. MA14998

Description

MA1-4998 detects Fc epsilonR1 alpha from human samples. The CRA2 (AER24) monoclonal antibody reacts with the Fc epsilonR1 alpha subunit on a region that overlaps the region of the IgE binding site, thus it competes with IgE for the receptor binding. Since MA1-4998 has been successfully used in Western blot, flow cytometry, and immunohistochemistry applications. The MA1-4998 immunogen is region of Fc epsilonR1 alpha which overlaps with the IgE binding site. The epitope has been mapped to amino acids 110-197.

FceR1 (Fc epsilonR1 alpha) is a subunit of the high affinity receptor of IgE. Fc epsilonR1 alpha is a tetrameric complex consisting of one alpha, one β and two additional subunits. The latter two are required for signal transduction activity. The Fc epsilonR1 complex plays an important role in triggering allergic responses, and the immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine, which are responsible for allergy symptoms, are released. The IgE receptor couples allergen and mast cells to initiate the inflammatory responses that are characteristic of disorders such as hay fever and asthma. The release of histamine and proteases leads to the synthesis of prostaglandins and leukotrienes-potent effectors of the hypersensitivity response.

Specifications

• Antigen: FceR1 alpha
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and no preservative; pH 7.4
• Gene Accession No.: P12319
• Gene Symbols: FCER1A
• Immunogen: Recombinant extracellular portion of recombinant human FcER1 alpha (corresponds to amino acids Met-26-197 excluding signal peptide 1-25).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1 κ

• Applications: Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
• Clone: CRA2 (AER24)
• Conjugate: Unconjugated
• Gene: FCER1A
• Gene Alias: alpha polypeptide; fc epsilon r1; Fc epsilon receptor Ia; Fc epsilon RI alpha-chain; Fc fragment of IgE receptor Ia; Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; Fc IgE receptor, alpha polypeptide; Fc receptor, IgE, high affinity I, alpha polypeptide; Fce1a; Fc-epsilon RI-alpha; fcepsilonri; FCER1A; FcERI; Fcr-5; high affinity immunoglobulin epsilon receptor alpha-subunit; high affinity immunoglobulin epsilon receptor subunit alpha; IgE Fc receptor subunit alpha; Iger01; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide; RATIGER01; RP11-550P17.3
• Host Species: Mouse
• Purification Method: purified
• Regulatory Status: RUO
• Gene ID (Entrez): 2205
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov