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Invitrogen™ FCHSD2 Polyclonal Antibody
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Catalog No. PIPA597739
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100 μg
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PIPA597739 100 μg
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Catalog No. PIPA597739 Supplier Invitrogen™ Supplier No. PA597739
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Description

Rabbit Polyclonal Antibody

FCHSD2 Polyclonal Antibody for Western Blot, IHC (P), ELISA

Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen FCHSD2
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 4 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
Gene FCHSD2
Gene Accession No. O94868
Gene Alias Carom; F-BAR and double SH3 domains protein 2; FCH and double SH3 domains 2; FCH and double SH3 domains protein 2; FCHSD2; KIAA0769; nervous wreck homolog; NWK; NWK1; Protein nervous wreck 1; SH3 multiple domains 3; SH3 multiple domains protein 3; SH3MD3
Gene Symbols FCHSD2
Host Species Rabbit
Immunogen Recombinant Human F-BAR and double SH3 domains protein 2 protein (1-290AA).
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9873
Target Species Human
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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