Invitrogen™ FCHSD2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA597739

Catalog No. PIPA597739

Description

FCHSD2 Polyclonal Antibody for Western Blot, IHC (P), ELISA

Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). [UniProt].

Specifications

• Antigen: FCHSD2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FCHSD2
• Gene Alias: Carom; F-BAR and double SH3 domains protein 2; FCH and double SH3 domains 2; FCH and double SH3 domains protein 2; FCHSD2; KIAA0769; nervous wreck homolog; NWK; NWK1; Protein nervous wreck 1; SH3 multiple domains 3; SH3 multiple domains protein 3; SH3MD3
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 9873
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 4 mg/mL
• Formulation: PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
• Gene Accession No.: O94868
• Gene Symbols: FCHSD2
• Immunogen: Recombinant Human F-BAR and double SH3 domains protein 2 protein (1-290AA).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov