Invitrogen™ FCRL2/FCRL5 Monoclonal Antibody (296902)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA524005

Catalog No. PIMA524005

Description

Detects human FCRL2/FcRH2 and FCRL5/FcRH5 in Western blots. In Western blots, approximately 25% cross-reactivity with recombinant human FCRL1, FCRL3, and FCRL4 is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

Fc receptor homologs, also known as IRTA2 proteins, are transmembrane proteins with sequence homology to classical Fc receptor families. FcRH2 (FCRL2) may have a regulatory role in normal and neoplastic B cell development. FcRH5 (FCRL5) expression is deregulated in multiple myeloma and Burkitt lymphoma cell lines with 1q21 abnormalities. FCRL5 may be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. It also may have an immunoregulatory role in marginal zone B-cells.

Specifications

• Antigen: FCRL2/FCRL5
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q96LA5, Q96RD9
• Gene Symbols: FCRL2, FCRL5
• Immunogen: Mouse myeloma cell line NS0-derived recombinant human FCRL2/FcRH2 Glu15-Asp395.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry, Western Blot
• Clone: 296902
• Conjugate: Unconjugated
• Gene: FCRL2
• Gene Alias: RP11-367J7.6, FCRH2, IFGP4, IRTA4, SPAP1, SPAP1A, SPAP1B, SPAP1C
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 79368, 83416
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized