Invitrogen™ FDFT1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA527995

Catalog No. PIPA527995

Description

Recommended positive controls: 293T, A431. Predicted reactivity: Mouse (90%), Rat (88%), Pig (93%), Rhesus Monkey (99%), Chimpanzee (100%), Bovine (92%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

FDFT1 catalyzes the first step in the cholesterol biosynthetic pathway, the conversion of trans-farnesyldiphosphate to squalene. The loss of promoter activity and response to sterols for FDFT1 is localized to a 69-bp section positioned 131 bp 5-prime to the transcription start site. Sequence analysis of this region shows that it contains a sterol regulatory element-1 (SRE1) previously identified in other sterol regulated genes and 2 putative NF1 binding sites.

Specifications

• Antigen: FDFT1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FDFT1
• Gene Alias: DGPT; EGK_18680; ERG9; farnesyl diphosphate farnesyl transferase 1; farnesyl diphosphate farnesyltransferase; farnesyl-diphosphate farnesyltransferase; farnesyl-diphosphate farnesyltransferase 1; FDFT1; FPP:FPP farnesyltransferase; presqualene-di-diphosphate synthase; SQS; Squalene synthase; squalene synthetase; SS
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2222
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.55 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P37268
• Gene Symbols: FDFT1
• Immunogen: Recombinant protein encompassing a sequence within the center region of human FDFT1. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG