Invitrogen™ FDPS Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596411

Catalog No. PIPA596411

Description

Immunogen sequence: IGGKYNRGLT VVVAFRELVE PRKQDADSLQ RAWTVGWCVE LLQAFFLVAD DIMDSSLTRR GQICWYQKPG VGLDAINDAN LLEACIYRLL KLYCREQPYY LNLIELFLQS SYQTEIGQTL DLLTAPQGNV DLVRFTEKRY KSIVKYKTAF YSFYLPIAAA MYMAGIDGEK EHANAKKILL EMGEFFQIQD DYLDLFGDPS VTGKIGTDIQ DNKCSWLVVQ CLQRATPEQY QILKENYGQK EAEKVARVKA LYEELDLPAV FLQYEEDSYS HIMALIEQYA APLPPAVFLG LARKIYKRRK; Positive Samples: 293T, HepG2, HeLa, MCF7, U-251MG, BxPC-3, Mouse liver, Mouse ovary, Rat liver, Rat testis; Cellular Location: Cytoplasm.

The isoprene biosynthetic pathway supply the cell with cholesterol, ubiquinone, and various nonsterol metabolites. The farnesylpyrophosphate synthetase enzyme catalyzes the formation of geranyl and farnesylpyrophosphate from isopentenylpyrophosphate and dimethylallyl pyrophosphate. Analysis of FDPS activity and protein in rat liver, accompanied by immunofluorescence and immunoelectron microscopy studies, demonstrated that FDPS is predominantly localized in peroxisomes. 1 Liver tissue from patients with the peroxisomal deficiency diseases Zellweger syndrome and neonatal adrenoleukodystrophy exhibit diminished activities of FDPS and subsequent isoprenoid synthesis.

Specifications

• Antigen: FDPS
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FDPS
• Gene Alias: (2E,6E)-farnesyl diphosphate synthase; 6030492I17Rik; Ac2-125; AI256750; cholesterol-regulated 39 kDa protein; CR 39; dimethylallyltranstransferase; Farnesyl diphosphate synthase; farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase); farnesyl diphosphate synthetase; farnesyl pyrophosphate synthase; farnesyl pyrophosphate synthetase; farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase; Fdps; Fdpsl1; FPP synthase; FPP synthetase; FPPS; FPS; geranyltranstransferase; KIAA1293; mKIAA1293; POROK9; testis-specific farnesyl pyrophosphate synthetase
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 110196, 2224, 83791
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 3.33 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P05369, P14324, Q920E5
• Gene Symbols: FDPS
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 120-419 of human FPS/FDPS (NP_0019951).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG