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Invitrogen™ Fe65 Polyclonal Antibody
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Catalog No. PIPA146191
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100 μL
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PIPA146191 100 μL
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Catalog No. PIPA146191 Supplier Invitrogen™ Supplier No. PA146191
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Description

Rabbit Polyclonal Antibody

Suggested positive control: IMR32 neuronal cell lysate, HEK 293 cell lysate, or brain lysate, antigen standard for APBB1 (transient overexpression lysate).

The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein, transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants have been described for this gene but some of their full length sequence is not known.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Fe65
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 1.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 15% glycerol and 0.02% sodium azide
Gene APBB1
Gene Accession No. O00213, P46933, Q9QXJ1
Gene Alias adaptor protein FE65a2; amyloid beta (A4) precursor protein-binding, family B, member 1; amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65); amyloid beta A4 precursor protein-binding family B member 1; amyloid beta precursor protein binding family B member 1; Amyloid-beta A4 precursor protein-binding family B member 1; APBB1; FE65; MGC:9072; Protein Fe65; RIR; stat-like protein
Gene Symbols APBB1
Host Species Rabbit
Immunogen Recombinant rat FE65, expressed in bacteria.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11785, 29722, 322
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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