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Invitrogen™ Fentanyl Monoclonal Antibody (5D8)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA549691

Catalog No. PIMA549691


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Description

Description

Antibody tested in indirect ELISA.

Fentanyl is a synthetic, lipophilic phenylpiperidine opioid agonist with analgesic and anesthetic properties. Fentanyl selectively binds to the mu-receptor in the central nervous system (CNS) thereby mimicking the effects of endogenous opiates. Stimulation of the mu-subtype opioid receptor stimulates the exchange of GTP for GDP on the G-protein complex and subsequently inhibits adenylate cyclase. This results in a decrease in intracellular cAMP and leads to a reduction in the release of neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline. The analgesic effect of fentanyl is likely due to its metabolite morphine, which induces opening of G-protein-coupled inwardly rectifying potassium (GIRK) channels and blocks the opening of N-type voltage-gated calcium channels, thereby resulting in hyperpolarization and reduced neuronal excitability. [National Center for Biotechnology Information. PubChem Compound Database; CID=3345].
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Fentanyl
Monoclonal
6.1 mg/mL
PBS with 0.09% sodium azide; pH 7.4
Mouse
Protein G
RUO
Chemical
Antibody
IgG
ELISA, Immunohistochemistry, Lateral Flow, SDS-Page
5D8
Unconjugated
C22H28N2O; Duragesic; Fentanest; Fentanil; Phentanyl
Conjugate of FT hapten and KLH.
200 μg
Primary
-20°C, Avoid Freeze/Thaw Cycles
Liquid
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