Invitrogen™ Fentanyl Monoclonal Antibody (5D8)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA549691

Catalog No. PIMA549691

Description

Antibody tested in indirect ELISA.

Fentanyl is a synthetic, lipophilic phenylpiperidine opioid agonist with analgesic and anesthetic properties. Fentanyl selectively binds to the mu-receptor in the central nervous system (CNS) thereby mimicking the effects of endogenous opiates. Stimulation of the mu-subtype opioid receptor stimulates the exchange of GTP for GDP on the G-protein complex and subsequently inhibits adenylate cyclase. This results in a decrease in intracellular cAMP and leads to a reduction in the release of neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline. The analgesic effect of fentanyl is likely due to its metabolite morphine, which induces opening of G-protein-coupled inwardly rectifying potassium (GIRK) channels and blocks the opening of N-type voltage-gated calcium channels, thereby resulting in hyperpolarization and reduced neuronal excitability. [National Center for Biotechnology Information. PubChem Compound Database; CID=3345].

Specifications

• Antigen: Fentanyl
• Classification: Monoclonal
• Concentration: 6.1 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Target Species: Chemical
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Immunohistochemistry, Lateral Flow, SDS-Page
• Clone: 5D8
• Conjugate: Unconjugated
• Gene Alias: C22H28N2O; Duragesic; Fentanest; Fentanil; Phentanyl
• Immunogen: Conjugate of FT hapten and KLH.
• Quantity: 200 μg
• Primary or Secondary: Primary
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid