Invitrogen™ FGD5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA590298

Catalog No. PIPA590298

Description

Immunogen sequence: YLGLLSENCL HSPRLAAAVR EFEQSVQGGS QTAKHRLLRV VQRLFQYQVL LTDYLNNLCP DSAEYDNTQG ALSLISKVTD RANDSMEQGE NLQKLVHIEH SVRGQGDLLQ PGREFLKEGT LMKVTGKNRR PRHLFLMNDV LLYTYPQKDG KYRLKNTLAV ANMKVSRPVM EKVPYALKIE TSESCLMLSA SSCAERDEWY G; Positive Samples: Mouse brain; Cellular Location: Cell projection, Cytoplasm, Early endosome, Endoplasmic reticulum, Golgi apparatus, cytoskeleton, ruffle membrane.

FGD5 activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. It mediates VEGF-induced CDC42 activation. It may regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation and may play a role in regulating the actin cytoskeleton and cell shape.

Specifications

• Antigen: FGD5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FGD5
• Gene Alias: C330025N11Rik; Fgd5; FYVE, RhoGEF and PH domain containing 5; FYVE, RhoGEF and PH domain-containing protein 5; mFLJ00274; ZFYVE23; Zinc finger FYVE domain-containing protein 23
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 232237
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.13 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q80UZ0
• Gene Symbols: FGD5
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1000-1200 of human FGD5 (NP_6897493).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov