Invitrogen™ FGF19 Monoclonal Antibody (117611)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA523861

Catalog No. PIMA523861

Description

This antibody shows approximately 10% cross-reactivity with recombinant human (rh) FGF-3 and rhFGF-5 and no cross-reactivity with rhFGF-4, rhFGF-6, rhFGF-7, rhFGF-9, rhFGF-10, rhFGF-13, rhFGF-16, rhFGF-17, rhFGF-18, rhFGF acidic, and rhFGF basic. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.

FGF19, Fibroblast growth factor 19, is a protein that in humans is encoded by the FGF19 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. The FGF19 gene is mapped to 11q13.3. The deduced 216-amino acid FGF19 protein contains asignal sequence and 2 cysteine residues that are conserved in the FGF family. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. FGF19 stimulates hepatic protein and glycogen synthesis but does not induce lipogenesis. The effects of FGF19 are independent of the activity of either insulin or the protein kinase Akt and, instead, are mediated through a mitogen-activated protein kinase signaling pathway that activates components of the protein translation machinery and stimulates glycogen synthase activity. The orthologous protein in mouse is FGF15, which shares about 50% amino acid identity and has similar functions. Together they are often referred to as FGF15/19.

Specifications

• Antigen: FGF19
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: O95750
• Gene Symbols: FGF19
• Immunogen: E. coli-derived recombinant human FGF-19 Phe27-Lys216.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Neutralization, Western Blot
• Clone: 117611
• Conjugate: Unconjugated
• Gene: FGF19
• Gene Alias: FGF; Fgf15; FGF19; FGF-19; Fibroblast growth factor; fibroblast growth factor 15; fibroblast growth factor 19; UNQ334/PRO533
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 9965
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized