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Invitrogen™ FGF19 Polyclonal Antibody
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Catalog No. PIPA5100905
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Quantity:
100 μL
Catalog No. Quantity
PIPA5100905 100 μL
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Catalog No. PIPA5100905

Supplier: Invitrogen™ PA5100905

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total FGF19.

FGF19, Fibroblast growth factor 19, is a protein that in humans is encoded by the FGF19 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. The FGF19 gene is mapped to 11q13.3. The deduced 216-amino acid FGF19 protein contains asignal sequence and 2 cysteine residues that are conserved in the FGF family. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. FGF19 stimulates hepatic protein and glycogen synthesis but does not induce lipogenesis. The effects of FGF19 are independent of the activity of either insulin or the protein kinase Akt and, instead, are mediated through a mitogen-activated protein kinase signaling pathway that activates components of the protein translation machinery and stimulates glycogen synthase activity. The orthologous protein in mouse is FGF15, which shares about 50% amino acid identity and has similar functions. Together they are often referred to as FGF15/19.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FGF19
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene FGF19
Gene Accession No. O95750
Gene Alias FGF; Fgf15; FGF19; FGF-19; Fibroblast growth factor; fibroblast growth factor 15; fibroblast growth factor 19; UNQ334/PRO533
Gene Symbols FGF19
Host Species Rabbit
Immunogen A synthesized peptide derived from human FGF19(Accession O95750), corresponding to amino acid residues M168-K216.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 170582, 9965
Target Species Human, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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