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Invitrogen™ FGFR1OP2 Polyclonal Antibody
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Catalog No. PIPA531050
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100 μL
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PIPA531050 100 μL
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Catalog No. PIPA531050 Supplier Invitrogen™ Supplier No. PA531050
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7, mouse stomach. Predicted reactivity: Mouse (98%), Rat (97%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

FGFR1OP2, also known as FGFR1 oncogene partner 2, is a gene that plays a crucial role in oncogenesis, particularly in myeloproliferative neoplasms. It is known to interact with the FGFR1 (Fibroblast Growth Factor Receptor 1) through chromosomal translocations that can lead to malignancies, such as the formation of the fusion protein FGFR1OP2-FGFR1 in KG-1a leukemic cells. FGFR1OP2 itself is a gene encoding a protein whose function is not entirely understood, but its association with FGFR1 highlights its potential role in oncogenic pathways. The FGFR1 component of the fusion is a receptor tyrosine kinase involved in various cellular processes like cell proliferation, migration, and differentiation. The disruption of these processes through abnormal expression or structural changes such as fusions can lead to uncontrolled cell growth and malignancies. FGFR1 is also frequently studied as a therapeutic target in cancer, given its importance in cellular signaling and cancer progression.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FGFR1OP2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene FGFR1OP2
Gene Accession No. Q9CRA9, Q9NVK5
Gene Alias 1500031J01Rik; FGFR1 oncogene partner 2; FGFR1 oncogene partner 2 homolog; FGFR1OP2; fibroblast growth factor receptor 1 oncogene partner 2; HSPC123; HSPC123-like; Wit3.0; Wit3.0_alpha; Wit3.0_beta; wound inducible transcript 3.0; wound inducible transcript 3.0 protein; wound-inducible transcript 3.0 protein
Gene Symbols FGFR1OP2
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human FGFR1OP2. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26127, 67529
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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