Invitrogen™ FGFR3 Monoclonal Antibody (1E3F9)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA548457

Catalog No. FERMA548457

Description

FGFR3 Monoclonal Antibody for Western Blot, ICC/IF, IHC, Flow, ELISA

FGFR3 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.

Specifications

• Antigen: FGFR3
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% sodium azide
• Gene Accession No.: P22607
• Gene Symbols: FGFR3
• Immunogen: Purified recombinant fragment of human FGFR3 (AA: 529-694) expressed in E. Coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: ELISA, Flow Cytometry, Immunohistochemistry, Western Blot, Immunocytochemistry
• Clone: 1E3F9
• Conjugate: Unconjugated
• Gene: FGFR3
• Gene Alias: ACH; CD333; CEK2; FGF Receptor; FGFR; FGFR3; FGFR-3; FGFR3deltaTM; Fibroblast growth factor receptor 3; fibroblast growth factor receptor 3 variant 4; Flg-2; FR3; HBGFR; heparin-binding growth factor receptor; HSFGFR3EX; hydroxyaryl-protein kinase; JTK4; Mfr3; sam3; tyrosine kinase JTK4
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 2261
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid