Invitrogen™ FGFR3 Monoclonal Antibody (T.994.9)

Catalog No.	Quantity
PIMA514843	100 μL

Catalog No. PIMA514843 Supplier Invitrogen™ Supplier No. MA514843

Description

Rabbit Monoclonal Antibody

It is not recommended to aliquot this antibody. This antibody is not cross-reactive with other related family members.

FGFR3 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.

Specifications

• Antigen: FGFR3
• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Classification: Monoclonal
• Clone: T.994.9
• Concentration: 27 μg/mL
• Conjugate: Unconjugated
• Formulation: 0.01M HEPES with 50% glycerol, 0.15M NaCl, 100μg/mL BSA and <0.02% sodium azide; pH 7.5
• Gene: FGFR3
• Gene Accession No.: P22607
• Gene Alias: ACH; CD333; CEK2; FGF Receptor; FGFR; FGFR3; FGFR-3; FGFR3deltaTM; Fibroblast growth factor receptor 3; fibroblast growth factor receptor 3 variant 4; Flg-2; FR3; HBGFR; heparin-binding growth factor receptor; HSFGFR3EX; hydroxyaryl-protein kinase; JTK4; Mfr3; sam3; tyrosine kinase JTK4
• Gene Symbols: FGFR3
• Host Species: Rabbit
• Immunogen: GST-FGFR-3 cytoplasmic domain fusion protein.
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2261
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG