FGFR3 Mouse anti-Human, Clone:1E3F9, Abnova™

Catalog No.	Quantity
89-333-096	100 μg

Catalog No. 89-333-096 Supplier Abnova Corporation Supplier No. MAB16731

Description

Mouse monoclonal antibody raised against recombinant human FGFR3.

This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq]

Specifications

• Antigen: FGFR3
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Clone: 1E3F9
• Conjugate: Unconjugated
• Description: fibroblast growth factor receptor 3
• Dilution: ELISA (1:10000)
  Western Blot (1:500-1:2000)
  Immunohistochemistry
  Immunocytochemistry
  Flow Cytometry
  The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.05% sodium azide)
• Gene: FGFR3
• Gene Alias: ACH, CD333, CEK2, HSFGFR3EX, JTK4
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to amino acid 529-694 of human FGFR3 from E. coli.
• Quantity: 100 μg
• Gene ID (Entrez): 2261
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a