Invitrogen™ FGFR3 Recombinant Rabbit Monoclonal Antibody (042)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA531141

Catalog No. PIMA531141

Description

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire. This antibody has specificity for Mouse FGFR3/CD333.

FGFR3 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.

Specifications

• Antigen: FGFR3
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: Q61851
• Gene Symbols: FGFR3
• Immunogen: Recombinant Mouse FGFR3/CD333 Protein (Met1-Tyr367).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA
• Clone: 042
• Conjugate: Unconjugated
• Gene: FGFR3
• Gene Alias: ACH; CD333; CEK2; FGF Receptor; FGFR; FGFR3; FGFR-3; FGFR3deltaTM; Fibroblast growth factor receptor 3; fibroblast growth factor receptor 3 variant 4; Flg-2; FR3; HBGFR; heparin-binding growth factor receptor; HSFGFR3EX; hydroxyaryl-protein kinase; JTK4; Mfr3; sam3; tyrosine kinase JTK4
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 14184
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid