Invitrogen™ FGFR5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5106797

Catalog No. PIPA5106797

Description

Antibody detects endogenous levels of total FGRL1.

Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuro-ectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors. A total of six members of the FGF receptor family have been identified and cloned. These include the Flg receptor or FGFR-1, the BEK receptor or FGFR-2, FGFR-3, FGFR-4, FGFR-5 and FGFR-6. These receptors usually contain an extracellular ligand-binding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. However, FGFR-5 lacks the cytoplasmic kinase domain. FGFR-5 is expressed in a broad range of tissues, including kidney, brain and lung, but it is preferentially expressed in pancreas, where it may play a role in the regulation of some pancreatic function.

Specifications

• Antigen: FGFR5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FGFRL1
• Gene Alias: alpha-L-iduronidase; FGF homologous factor receptor; FGF receptor-like protein 1; Fgfr5; FGFR-5; FGFR5beta; FGFR5gamma; Fgfrl1; FGFR-like protein; FHFR; fibroblast growth factor receptor 5; Fibroblast growth factor receptor-like 1; fibroblast growth factor receptor-like protein; UNQ480/PRO943
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 116701, 53834
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q8N441, Q91V87
• Gene Symbols: FGFRL1
• Immunogen: A synthesized peptide derived from human FGFRL1(Accession Q8N441), corresponding to amino acid residues N321-S371.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov