Invitrogen™ FGFR5 Recombinant Rabbit Monoclonal Antibody (004)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA529293

Catalog No. PIMA529293

Description

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire. This antibody has specificity for Mouse FGFRL1/FGFR5.

Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuro-ectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors. A total of six members of the FGF receptor family have been identified and cloned. These include the Flg receptor or FGFR-1, the BEK receptor or FGFR-2, FGFR-3, FGFR-4, FGFR-5 and FGFR-6. These receptors usually contain an extracellular ligand-binding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. However, FGFR-5 lacks the cytoplasmic kinase domain. FGFR-5 is expressed in a broad range of tissues, including kidney, brain and lung, but it is preferentially expressed in pancreas, where it may play a role in the regulation of some pancreatic function.

Specifications

• Antigen: FGFR5
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: Q91V87
• Gene Symbols: FGFRL1
• Immunogen: Recombinant Mouse FGFRL1/FGFR5 Protein (Met1-Pro374).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA
• Clone: 004
• Conjugate: Unconjugated
• Gene: FGFRL1
• Gene Alias: alpha-L-iduronidase; FGF homologous factor receptor; FGF receptor-like protein 1; Fgfr5; FGFR-5; FGFR5beta; FGFR5gamma; Fgfrl1; FGFR-like protein; FHFR; fibroblast growth factor receptor 5; Fibroblast growth factor receptor-like 1; fibroblast growth factor receptor-like protein; UNQ480/PRO943
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 116701
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid